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Overview
TEER |
TEER™ (Template Exchange Extension Reaction) is a proprietary, patented technology platform to screen for rare and unknown single nucleotide polymorphisms (SNPs). It provides the highest level of sensitivity for SNP analysis and allows for detection of rare mutations in patient specimens. TEER uses a common off-the-shelf platform – Real-Time PCR – for amplification and detection, which makes it a low-cost and accessible screening method for any research or clinical reference laboratory.
Advantages of TEER
A quick, highly sensitive and cost-effective technique to screen for rare and unknown SNPs, TEER offers several advantages over other genetic screening technologies:
- Ability to detect rare and unknown mutations: Many methods for SNP analysis are allele-specific and only allow for the identification of a known mutation, which can be costly on a per sample basis. TEER can detect both known and unknown mutations.
- Unparalleled sensitivity: Sequencing techniques can identify all known and unknown mutations within a sample, but sequencing has a detection sensitivity ratio of 1:4. This means that a genetic mutation must be present in 25 percent of a sample’s cells to be detected. TEER is being developed to reach sensitivity levels of 1:10,000 or greater.
- Efficient, cost-effective and easy to use: Other techniques to screen for unknown mutations can be very cumbersome or costly to perform, requiring significant lab resources. TEER is both easy to use and cost-effective.
